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These results show that the Col-Gd@Tub NCs may be served as a versatile nanoscale platform for integration of biomedical imaging probe and therapeutic molecules for tumor therapy. © 2020 IOP Publishing Ltd.Semiconductor quantum dots/ graphene oxide (QDs/GO) hybrid composites, as emerging materials, have recently attracted intensive attentions in materials science and technology due to their potential applications in electronic and photonic devices. Here, a simple and universal strategy to produce DNA-programmed semiconductor quantum d