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Finally, we also identified papers which describe model evaluation methods (4 papers). Three classes of approaches were identified to assess heterogeneity of treatment effect. Methodological research, including both simulations and empirical evaluations, is required to compare the available methods in different settings and to derive well-informed guidance for their application in RCT analysis. Three classes of approaches were identified to assess heterogeneity of treatment effect. Methodological research, including both simulations an