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The saponin content in Gynostemma pentaphyllum extracts achieved 82.81%, that has been more than four times of that acquired with resin adsorption strategy. The safety aftereffect of saponins on SH-SY5Y cells injury induced by H2O2 was a lot better than compared to Gynostemma pentaphyllum extracts. The research suggested that ultrasonic assisted membrane method would be widely used into the planning of meals products.In this research, Hovenia dulcis fruit fermented v