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How to Choose the Best ADHD Medication for Adults With Anxiety and Depression If a person suffers from both ADHD and anxiety or depression treating one condition usually improves the other. Mental health specialists prescribe antidepressants, stimulants for depression or antidepressants, along with ADHD medication. Wellbutrin (bupropion) and Effexor, (venlafaxine), are two of the most popular antidepressants prescribed to treat ADHD "off-label". These medications bo