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We desired to additional investigate dysregulated NO signaling and also to analyze the consequences of a NO-based twin therapy (sodium nitrite+hydralazine) after the start of HFpEF making use of a "2-hit" murine design. Techniques and Results Nine-week-old male C57BL/6 N mice (n=15 per team) were addressed concurrently with high-fat diet and N(ω)-nitro-L-arginine methyl ester (L-NAME) (0.5 g/L per day) via normal water for 10 days. At week 5, mice were randomized i
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