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The fusion regarding the exterior (OMM) and internal mitochondrial membranes (IMM) is mediated by two classes of dynamin-like protein (DLP) mitofusin (MFN)/fuzzy onions 1 (Fzo1) and optic atrophy 1/mitochondria genome maintenance 1 (OPA1/Mgm1). Because of the lack of structural information about these fusogens, the molecular systems fundamental mitochondrial fusion remain uncertain, even with two decades. Here, we examine current improvements in architectural studies for the mitochondrial fusion machinery, disc