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Here, we critically address the bidirectional interplay between interferons (focusing on type I) and cell senescence, with important implications for health and healthspan.With the development of hydrogen-energy economy, it is urgent for researchers to explore high effective non-noble metal electrocatalysts for oxygen evolution reaction (OER). Nickel-based selenides have good conductivity and easy to regulate, which make them to be a promising OER electrocatalysts. Hence, many researchers engineering the structure of Nickel-based seleni