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Diabetic retinopathy (DR) is one of the most really serious problems of diabetic issues, that leads to loss of sight. By dealing with the original treatment limitations, we developed a novel light-responsive targeted polymeric microcapsule in a position to encapsulate a near infrared (NIR) photoactive fluorophore - Indocyanine Green, due to its photothermal properties. More over, for a competent in vitro targeted medication distribution, the fluorescent microsystem was conjugated with a therapeutic b