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Finally, overexpression of miR‑449a or inhibition of SCN2B promoted the extension of hippocampal neurons in vitro. The results of the present study suggested that miR‑449a was downregulated in the prefrontal cortex and hippocampus of SAMP8 mice and may regulate the process of brain aging by targeting SCN2B.Following the publication of this article, the authors have realized that Table I was not included with the printed version of the article, although it was referenced in the text. Subsequently, it has been determined that a processing