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The Most Effective ADHD Medication For Adults Adults suffering from ADHD are usually prescribed stimulants. They help adjust levels of two chemical messengers within the brain that regulate attention. The most effective medication for adhd for adults is Strattera (atomoxetine). It is available as capsules that can be taken with food or without. It is effective for a majority of people. It lasts longer than stimulants with an action time that is shorter like amphetamine and methylphenidate. 1.