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How to Choose the Best ADHD Medication for Adults With Anxiety and Depression When a person suffers from both ADHD and depression or anxiety, treating the first condition can often help the second. Mental health professionals usually prescribe antidepressants or stimulants for depression in addition to an ADHD medication. Wellbutrin (bupropion) and Effexor (venlafaxine) are the most frequently used antidepressants that are prescribed "off-label" for ADHD. These medications increase t