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T02873039). Baicalein and simvastatin possess similar pharmacological activities and indications. The risk of their co-administration was unclear. The interaction between baicalein and simvastatin was investigated to provide reference and guidance for the clinical application of the combination of these two drugs. The pharmacokinetics of simvastatin was investigated in Sprague-Dawley rats (  = 6). The rats were pre-treated with 20 mg/kg baicalein for 10 days and then administrated with 40 mg/kg simvastatin. The single administration of