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This study investigated the ability of SDF, and its individual components, silver (Ag ) and fluoride (F ) ions, in preventing enamel demineralization under pH-cycling conditions in the presence or absence of twice-daily fluoride application. Polished human enamel specimens were assigned to five treatment groups (n = 36 per group) SDF (38 %); SDF followed by application of a saturated solution of potassium iodide (SDF + KI); silver nitrate (AgNO ; silver control, 253,900 ppm Ag); potassium fluoride (KF; fluoride control, 44,800 ppm F); deionized water. Treat