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s a primary treatment or adjunct therapy in paracetamol poisoning. Calmangafodipir remains investigational. The vast majority of patients with acute paracetamol overdose enjoy excellent outcomes with acetylcysteine alone. Although cimetidine and fomepizole inhibit CYP 2E1 in animals, there is insufficient evidence to recommend their use either as a primary treatment or adjunct therapy in paracetamol poisoning. Calmangafodipir remains investigational.Individuals with severe self-harm and experiences of lengthy psychiatric admissions often have comple