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The 3-year OS was 78.1% (95% CI 72.4-84.2%) for the high-risk group and 95% (95% CI 93.6-96.5%) in the low-risk group (HR 4.42, 95% CI 3.22-6.05; P0.001). This finding was also applied in the two external cohorts. Similarly, a nomogram that contained the same indices was developed and validated to predict for DFS. Nomograms based on pathological findings are a reliable tool to predict 3-year OS and DFS rate in patients with locally advanced rectal cancer. Nomograms based on pathological findings are a reliable tool to predict 3-year