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The agreement between the two methods (reference and test) was evaluated in terms of Bu exposure differences based on Lin's concordance correlation coefficient (CCC) and represented by the Bland-Altman plot. The CCC between the AUC of the two methods was excellent (0.868; 95% CI 0.802-0.935). The precision of the measures (expressed by Pearson's italic "r" was 0.872, and the accuracy (accounted by the bias correction factor) was 0.996. We can conclude that the HPLC-MS/MS assay represents a very good alternative to the reference. We can
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