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How to Choose the Best ADHD Medication for Adults With Anxiety and Depression If someone has ADHD and anxiety or depression treating one condition usually improves the other. Mental health professionals prescribe antidepressants, stimulants for depression, or antidepressants, along with ADHD medication. Wellbutrin (bupropion), and Effexor, (venlafaxine), are two of the most popular antidepressants prescribed to treat ADHD "off-label". These medications increase levels of neurotransmitters like norepinephrine and dopamine. They also aid in improving concentration.