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ADHD Medications - Stimulant Or Non Stimulant? Stimulant medication is the first choice for ADHD treatment, because they're the most researched and have a fast-acting effect. However, they aren't for everyone. These medications enhance the signaling between brain regions and nerves to reduce ADHD symptoms. They can also cause negative side effects, such as a loss of appetite and changes in heart rate or blood pressure. Stimulants St