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ADHD Medications - Stimulant Or Non Stimulant? Stimulant medications are first-choice ADHD medications, they with the most research-based backing behind them, and are fast-acting. However, they're not suitable for everyone. These medications increase the signaling between nerves and areas in the brain, thereby reducing symptoms of ADHD. They can also trigger adverse effects such as a loss of appetite and changes in blood pressure or heart rate. Stimulants Stimulants are among the most popular treatments for A