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cent reduction in the incidence and duration of opioid management. To evaluate the association between incident cardiovascular disease (CVD) and initiation and adherence to statin treatment for primary prevention of CVD in patients with newly diagnosed hypercholesterolaemia. A population-based retrospective cohort study. This study used National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) from Republic of Korea. This study included 11 320 participants without previous history of CVD aged between 40 and 79 years who had