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How Does ADHD Medication Work? When a neuron transmits an electrical signal to another, it makes use of neurotransmitters, which are chemicals that act as. These need to traverse a small gap, which is known as the synapse. Some ADHD medications can increase the efficiency of these messages. They can help neurons release more neurotransmitters or slow down the process of reuptake (called reuptake inhibitors). Doctors start people with ADHD with a low dose of medication and t