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Nanoparticulate titanium dioxide (Nano-TiO ) has been widely used in food industry, and it has been demonstrated to have adverse effects on mice and human stomach, but its mechanism is rarely concerned. The aim of this study is to determine the effects of nano-TiO on the stomach and confirm the role of oxidative stress and apoptosis in the mice gastric damage caused by nano-TiO , as well as its molecular mechanisms. Mice were continuously exposed to nano-TiO with 1.25, 2.5 and 5mg/kg bw by intragastric administration for 9 months in the