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001). The adequacy of the four factors for DCB optimization was an independent predictor of TLF (adjusted hazards ratio for each unmet criteria for optimization, 2.05, 95% confidence interval 1.74-2.36, p  .001). The optimization of the four procedural factors could reduce TLF following DCB treatment. The optimization of the four procedural factors could reduce TLF following DCB treatment.Rasopathies are a group of phenotypically overlapping conditions that include Noonan, Noonan with multiple lentigines, Noonan with loose anagen ha