https://www.selleckchem.com/pr....oducts/10-dab-10-dea
Intervertebral disc (IVD) degeneration is associated with low back pain and accompanied by mechanical changes to the spine. SPARC (secreted protein acidic and rich in cysteine) is a protein that contributes to the functioning and maintenance of the extracellular matrix. SPARC-null mice display accelerated IVD degeneration and pain-associated behaviours. This study examined if SPARC-null mice also display altered spine mechanics as compared to wild-type (WT) mice. Lumbar spines from SPARC-null (n=36) and WT (n=18) mice
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