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Therefore, in this study, a novel liposomal system, including a lipophilic simple oil called a lipo-oil-some (LOS), had been designed to increase the chemical stability and aid your skin absorption of Vit C. The vesicular methods had been prepared utilising the ethanol injection strategy, employing phosphatidylcholine, cholesterol, dipalmitoyl-sn-glycerol-3-phosphoglycerol, and tricaprylin as simple oil. The optimized LOS had been characterized the following shape, multi-layered sphere; size, 981