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How Does ADHD Medication Work? When a neuron transmits a signal to another, it uses neurotransmitters or chemicals. These chemicals must pass through a tiny gap known as a synapse. Some ADHD medications increase the efficiency of these messages. They may assist neurons in the release of more neurotransmitters or slow the reuptake process (called reuptake inhibitors). Doctors start ADHD patients on a low dosage and monitor their response. They adjust the dosage gradually to find the