https://gsk3-signal.com/index.....php/limitations-with
AML in DS children (ML-DS) is described as the pathognomonic mutation in the gene encoding the primary hematopoietic transcription factor GATA1, resulting in N-terminally truncated short kind of GATA1 (GATA1s). Trisomy 21 and GATA1s together are sufficient to cause transient irregular myelopoiesis (TAM) exhibiting pre-leukemic characteristics. Approximately 30% of the cases progress into ML-DS by acquisition of extra somatic mutations. We employed infection modeling in vitro by the
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