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on. The zoonotic P. knowlesi is similar to other Plasmodium spp in compromising DC in adult malaria. South Africa aims to eliminate malaria transmission by 2023. However, despite sustained vector control efforts and case management interventions, the Vhembe District remains a malaria transmission hotspot. To better understand Plasmodium falciparum transmission dynamics in the area, this study characterized the genetic diversity of parasites circulating within the Vhembe District. A total of 1153 falciparum-positive rapid diagnostic test
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