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ETHNOPHARMACOLOGICAL RELEVANCE Licorice is an ancient food and medicinal plant. Liquiritigenin and liquiritin, two kinds of major flavonoes in licorice, are effective substances used as antioxidant, anti-inflammatory and tumor-suppressive in food, cosmetics or medicines. However, their in vivo metabolites have not been fully explored. AIM OF STUDY To clarify the metabolism of liquiritigenin and liquiritin in mice. MATERIALS AND METHODS In this study, we developed a liquid chromatography coupled with quadrupole/time-of-flight mass spect
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