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Pregabalin use was associated with greater pain severity and interference and greater use of high-risk opioid doses (90 oral morphine equivalents/day). Pregabalin use was not associated with changes in mental health symptoms, ambulance or emergency department attendance in the fixed or random effects models. Pregabalin use was common, but for most people use was not associated with clinically meaningful improvements in pain or functioning. Pregabalin use was common, but for most people use was not associated with clinically meaningfu