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[the original article was published in Oncology Reports 34 87-94, 2015; DOI 10.3892/or.2015.3961].As a specific microvascular complication of diabetes, diabetic retinopathy (DR) causes severe visual impairment in patients with diabetes. The expression of microRNA‑126 (miRNA/miR‑126) has previously been found to be significantly decreased in the serum of patients with DR. In the present study, the functions of miR‑126 and its mechanisms of action in experimental diabetic retinopathy were examined in rats with streptozotocin (STZ)‑induced