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The observed Zn2+-promoted TDP-43 CTF's solid-like phase separation can be relevant to the Zn2+ dyshomeostasis in ALS and FTLD-TDP.Hydrogel-based piezoresistive sensors have high practical value in many revolutionary applications, such as intelligent and electronic devices. However, with existing hydrogels, it is very difficult to achieve a combination of good mechanical properties, stable conductivity, and simple/green fabrication method. In this study, hybrid organic-inorganic nanoparticles (lignin-silver hybrid nanoparticles, Lig-A