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This installment of the Core Curriculum in Nephrology outlines several practical applications of kidney supportive care, with a focus on the nephrologist's approach to symptom management, active medical management of kidney failure without dialysis (also known as comprehensive conservative care), acute kidney injury in seriously ill patients, and withdrawal from dialysis. RATIONALE OBJECTIVES Dialysis patients frequently experience medication-related problems. We studied the association of a multidisciplinary medication therapy man