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Cisplatin (Cis) is an efficient chemotherapeutic drug; nonetheless, its intense nephrotoxicity frequently restricts its application. The role of liraglutide (Lir), an agonist associated with the glucagon-like peptide-1 receptor (GLP-1R), has attracted increasing interest beyond glycemic regulation. This research showed that Lir significantly ameliorated Cis-induced kidney disorder and renal harm. However, this renoprotective result ended up being partly abolished in GLP-1R knockou