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This will be a retrospective cross-sectional research conducted in the Clinical and Molecular Cytogenetics Laboratory of NIBD Hospital, Karachi, Pakistan. The rates of tradition failure are considered through the year 2017-2020 along making use of their reasons. Bone Marrow aspirate types of customers with hematological malignancies were cultured for chromosomal evaluation, both during the time of diagnosis or relapse. Analytical analysis ended up being performed making use of SPSS v