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50, 95%CI 1.15, 1.95] and lower wellbeing [ß -0.15, 95%CI -0.26, -0.04]. Findings were similar when using the metabolically favourable and unfavourable adiposity variants, with higher adiposity associated with higher odds of depression and lower wellbeing scores. Our study provides further evidence that higher BMI causes higher odds of depression and lowers wellbeing. Using genetics to separate out metabolic and psychosocial effects, our study suggests that in the absence of adverse metabolic effects higher adiposity remains causal to
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