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Genetic analysis carried out through PCR showed 220bp amplicons. The 25% of patients with CPSP showed a Numeric Rating Scale (NRS) 4 pain score. The 20% of these patients have known Val158Met mutation, 5% of patients showed novel mutations c.382CG, c.383GC, p.(Arg128Ala). The mutations in COMT gene contributed major structural variations in COMT leading to the formation of inactive COMT that correlates with CPSP. The results of the present study showed that both novel and previously reported mutations in COMT gene has strong
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