https://www.selleckchem.com/pr....oducts/Ubenimex(Best
Tumor necrosis factor α (TNFα) and its receptors contribute to rejection of transplanted cells and organs. To elucidate how TNFα affects xenograft rejection, we previously cloned the cDNA of pig TNF-receptor 2 (pTNFR2) and found four isoforms one comprising the full receptor with four cysteine-rich domains (CRD), a shorter variant (pTNFR2ΔE7-1 encoding for a soluble isoform, another lacking exon 4 (pTNFR2ΔE4) displaying only 3 CRD and poor ligand binding, and the smallest one generated by the two alternative splicings. All
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