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Medication For ADHD - What Are the Side Effects? Many people who suffer from ADHD have a decrease in symptoms when they use medication. Every person's reaction to medication is different, and the side effects can be a problem. Methylphenidate belongs to a class of medications called stimulants. It increases the levels of a chemical in the brain that helps control the behavior and focus. Stimulant medication Stimulants enhance concentration and attention in 70% to 80% of adults and children who take them. They work by altering neurotransmitters such