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ADHD Medications For Adults Stimulants aid in adjusting the levels of chemical messengers in the brain that control attention. They are first-line medications in the treatment of ADHD. Although they are not in any way habit-forming, they can trigger negative side effects, such as headaches and difficulty sleeping. Your doctor could prescribe Guanfacine (brand names Tenex and Intuniv) or clonidine (Catapres) to decrease hyperactivity and impulsivity. These drugs have a