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The first-generation NA, lamivudine, paid off the possibility of HCC at three years in comparison to placebo; however, its large emergence of antiviral resistance has made it no more recommended when you look at the international guidelines. Recent heated debate is approximately the two current first-line NAs-entecavir and tenofovir disoproxil fumarate (TDF)-Are they coequally as good as to lessen HCC threat in CHB customers? A small number of cohort tests also show two different types of observations-TDF is