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Previously, we have shown treatment with interleukin-33 can lessen choroidal neovascularization and attenuate tissue remodelling. Right here, we investigate IL-33 distribution in aged, high-fat diet (HFD) provided mice on a wildtype and complement factor H heterozygous knockout back ground. We characterize the non-toxic result after intravitreal injection of IL-33 and further demonstrate defensive effects against RPE cell demise with proof maintaining metabolic retinal h