https://www.selleckchem.com/pr....oducts/imlunestrant.
Hippo/YAP1 signaling is a major regulator of organ size, cancer stemness and aggressive phenotype. Thus, targeting YAP1 may provide a novel therapeutic strategy for tumors with high YAP1 expression in esophageal cancer (EC). Chromatin immunoprecipitation (ChiP) and quantitative ChiP-PCR were used to determine the regulation of the chromatin remodeling protein bromodomain-containing protein 4 (BRD4) on YAP1. The role of the bromodomain and extra-terminal motif (BET) inhibitor JQ1, an established BRD4 inhibitor, on inhibition of YAP1
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