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1%) in human skin from the KETO-THP construct as compared to drug solution (38%) and excellent immediate release from THP-solubilized construct (90% less then 1 h). Hence, THP could be a better option for topical, transdermal, and oral formulation.Chemicals such as anionic surfactants and polymers often contain groups that complex divalent ions such as Ca2+. The formation of divalent ion complexes can decrease emulsifying or viscosifying power and lead to adsorption or precipitation. This is particularly relevant in chemical enhanced oil