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Practitioner summary In a full-motion cabin simulator study with 124 passengers the level of inflight anxiety and inflight sickness severity was monitored. Trait anxiety and motion sickness history were found to have different impacts on the temporal progression of individual sickness severity. Abbreviations ANOVA analysis of variance; AVES air vehicle simulator; hiA/hiM group with high anxiety and high motion sickness susceptibility; hiA/loM group with high anxiety and low motion sickness susceptibility;MSSQ motion sickness susceptibil