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We report synthesis and enzymatic assays on human histone lysine methyltransferase catalysed methylation of histones that possess lysine and its geometrically constrained analogues containing rigid (E)-alkene (KE), (Z)-alkene (KZ) and alkyne (Kyne) moieties. Methyltransferases G9a and GLP do have a capacity to catalyse methylation in the order K ≫ KE KZ ∼ Kyne, whereas monomethyltransferase SETD8 catalyses only methylation of K and KE.It remains challenging to develop new materials exhibiting enzyme-like activities and understand t
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