https://nuciferineantagonist.c....om/the-situation-for
In this research we developed an obesity linked pre-HFpEF mouse design and revealed an improvement both in systolic and diastolic early dysfunction following fecal microbiome transplant (FMT). Our study implies that the gut microbiome-derived short-chain fatty acid butyrate plays a substantial part in this enhancement. Cardiac RNAseq analysis revealed butyrate to significantly upregulate ppm1k gene that encodes protein phosphatase 2Cm (PP2Cm) which dephosphorylates and triggers branched-chain α-keto a
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