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e findings pave an avenue for the development of novel prophylactic and therapeutic strategies for peripheral nerve injury. © 2018 Shenyang Pharmaceutical University. Published by Elsevier B.V.Upon the discovery of RNA interference (RNAi), canonical small interfering RNA (siRNA) has been recognized to trigger sequence-specific gene silencing. Despite the benefits of siRNAs as potential new drugs, there are obstacles still to be overcome, including off-target effects and immune stimulation. More recently, Dicer substrate siRNA (DsiRNA) h
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