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Meanwhile, treatment with Akt inhibitor LY294002 reversed the protective effects of isorhamnetin against HG-aggravated OGD/R injury in HT22 cells. In a conclusion, Isorhamnetin alleviates HG-aggravated OGD/R in HT22 hippocampal neurons through Akt/SIRT1/Nrf2/HO-1 signaling pathway.Here, we present a conceptual and quantitative model to describe the role of the Cytochrome [Formula see text] complex in controlling steady-state electron transport in [Formula see text] leaves. The model is based on new experimental methods to diagnose the