https://www.selleckchem.com/pr....oducts/simufilam.htm
EcPKR is mainly present in the cytoplasm. Overexpression of EcPKR in grouper spleen (GS) cells inhibits the transcription of the RGNNV genes. Furthermore, our results show that EcPKR overexpression significantly enhances the immune response of interferon and the activation of interferon-beta (IFN-β), interferon stimulated response element (ISRE) and nuclear factor-kappa B (NF-κ. Taken together, these results are important for better understanding of the function of PKR in fish and reveal its involvement in host response to immune ch
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